全部产品分类
品牌 |
Leading Biology | 货号 |
LM21071 |
产品分类 |
单克隆抗体 | 研究领域 |
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产品概述 |
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
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形式 |
Synaptojanin is an inositol 5?0phosphatase and take part in membrane trafficking processes and signal transduction (1). Two isoform of Synaptojanin exists, Synaptojanin 1 (aka Synaptojanin) and Synaptojanin 2. Synaptojanin is mainly expressed in nerve terminals and is involved in clathrin-mediated synaptic vesicle recycling in neuronal cells (2). Ubiquitously expressed and with high catalytic domains homology to Synaptojanin, Synaptojanin 2 is considered as a Rac1 effector. Synaptojanin 2 possibly medicates the inhibitory effect of Rac1 on clathrin-mediated endocytosis. Synaptojanin 2 contributes to Rac1?s role in cell invasions and migration by regulation the formation of specialized membrane structures in ECM (invaodopoida and lamellipoida). Synaptojanin 2 is considered to be a novel target for therapeutic intervention in malignant tumors.
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浓度 |
A synthetic peptide corresponding to residues near the N-terminus of human Synaptojanin 2 is used as an immunogen. |
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纯度 |
Rabbit |
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试剂准备 |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
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复溶 |
1. Nemoto Y, et al., ASNMN 272(49):30817-21, 1997.<br>2. Rusk N, et al., Curr Biol 13(8):659-63, 2003.<br>
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储存条件 |
Human
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储存溶液 |
Synaptojanin-2, Synaptic inositol 1, 5-trisphosphate 5-phosphatase 2, SYNJ2, KIAA0348
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应用 |
WB~~1:500000
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产品描述 |
Function
Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis.
Cellular_Location
Membrane. Note=Predominantly associated with the particulate fractions.
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数量 |
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