全部产品分类
品牌 |
Leading Biology | 货号 |
LM21051 |
产品分类 |
单克隆抗体 | 研究领域 |
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形式 |
Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
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浓度 |
This Protein-A purified antibody is directed against human STAT2 protein. A BLAST analysis was used to suggest cross-reactivity with STAT2 protein from human, rat (73%) and mouse (76%), sources based on homology with the immunizing sequence. Reactivi ... |
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纯度 |
Mouse |
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复溶 |
Fu X.-Y.,et al.Proc. Natl. Acad. Sci. U.S.A. 89:7840-7843(1992).
Yan R.,et al.Nucleic Acids Res. 23:459-463(1995).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.E.,et al.Nature 440:346-351(2006).
Fu X.Y.,et al.Cell 70:323-335(1992).
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储存条件 |
Human, Mouse
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储存溶液 |
Signal transducer and activator of transcription 2, p113, STAT2
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应用 |
ELISA (1:5000-1:10000), IHC-P (10 μg/ml), WB (1:1000)
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产品描述 |
Function
Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
Cellular_Location
Cytoplasm. Nucleus. Note=Translocated into the nucleus upon activation by IFN-alpha/beta
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数量 |
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