全部产品分类
品牌 |
Leading Biology | 货号 |
LM21048 |
产品分类 |
单克隆抗体 | 研究领域 |
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产品概述 |
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
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形式 |
ST13/HIP is a cytoplasmic co-chaperone involved in the regulation of Hsc70 chaperone activity and the maturation of progesterone receptor. ST13/HIP is made of two structural and functional domains, an NH2-terminal domain, responsible for the dimerization and the overall asymmetry of the molecule, and a COOH-terminal globular domain, both involved in Hsc70 and unfolded protein binding (1). By collaborating with other positive co-factors such as Hsp40 and the Hsp70-Hsp90 organizing protein (Hop), or competing with negative co-factors such as Bcl2-associated athanogen 1 (Bag1), ST13/HIP facilitates may facilitate the chaperone function of Hsc/Hsp70 in protein folding and repair, and in controlling the activity of regulatory proteins such as steroid receptors and regulators of proliferation or apoptosis (2).
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浓度 |
A synthetic peptide corresponding to residues near the C-terminus of human Hsc70 Interacting Protein/HIP was used as an immunogen. |
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纯度 |
Rabbit |
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试剂准备 |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
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复溶 |
1. Velten M, et al. J Biol Chem. 277(1):259-66, 2002<br>2. Shi ZZ, et al. J Zhejiang Univ Sci B. 8(3):170-6, 2007<br>
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储存条件 |
Human, Mouse
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储存溶液 |
Hsc70-interacting protein, Hip, Aging-associated protein 2, Progesterone receptor-associated p48 protein, Protein FAM10A1, Putative tumor suppressor ST13, Renal carcinoma antigen NY-REN-33, Suppression of tumorigenicity 13 protein, ST13, AAG2, FAM10A1, HIP, SNC6
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应用 |
WB~~1:1000~10000
IHC~~1:100~250
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产品描述 |
Function
One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity).
Cellular_Location
Cytoplasm.
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数量 |
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