全部产品分类
品牌 |
Leading Biology | 货号 |
LM21031 |
产品分类 |
单克隆抗体 | 研究领域 |
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形式 |
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein- tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.
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浓度 |
Mouse SOCS-1 |
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纯度 |
Mouse |
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复溶 |
Minamoto S.,et al.Biochem. Biophys. Res. Commun. 237:79-83(1997).
Ohya K.,et al.J. Biol. Chem. 272:27178-27182(1997).
Starr R.,et al.Nature 387:917-921(1997).
Yandava C.N.,et al.Genomics 61:108-111(1999).
Schlueter G.,et al.Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
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储存条件 |
Human, Mouse
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储存溶液 |
SOCS1, CIS1, CISH1, JAB, JAK-binding protein, JAK binding protein, STAT-induced STAT inhibitor 1, SSI-1, Tec-interacting protein 3, TIP3, SOCS-1, SSI1, STAT induced SH3 protein 1, TIP-3
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应用 |
IHC-P (10 μg/ml), WB (1 - 10 μg/ml),
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产品描述 |
Function
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein- tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.
Cellular_Location
Nucleus. Cytoplasmic vesicle. Note=Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3
Tissue_Location
Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes
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数量 |
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| 选择 | 品牌 | 货号 | 产品名称 | 规格 | 分类 | 研究领域 | 说明书 | 数量 | 目录价 | |
| 1 | Swant | 2D7 | monoclonal anti-Glutamate antibody | 200 µl | 单克隆抗体 | Antibodies against neurotransmitters |
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￥5096.00 | 订购 询价 | |
| 2 | Leading Biology | LM21248 | Anti-CD36 Antibody (Rabbit Monoclonal antibody) | 100 ul | 单克隆抗体 | Chondrogenesis Markers |
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| 3 | Swant | 288 | Monoclonal antibody to endothelial cells. | 单克隆抗体 |
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| 4 | Swant | 345 | Monoclonal antibody to rat pyramidal cells. | 200 µl | 单克隆抗体 | Miscellaneous antibodies |
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￥3243.00 | 订购 询价 | |
| 5 | Swant | 3A12 | monoclonal anti-GABA antibody | 200 µl | 单克隆抗体 | Antibodies against neurotransmitters |
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| 6 | Swant | 77 | mouse monoclonal antibody against rat angiotensinogen | 200 µl | 单克隆抗体 | Antibodies against components of the renin-angiotensin system |
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￥4015.00 | 订购 询价 |
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