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当前位置:首页 > 抗原抗体、ELISA、WB > 一抗 > 单克隆抗体 > SMAD7 Antibody (monoclonal) (M05)

SMAD7 Antibody (monoclonal) (M05)

LM21022
货号 货期 规格 / 价格 询价

SMAD7 Antibody (monoclonal) (M05)

品牌

Leading Biology

货号

LM21022

产品分类

单克隆抗体

研究领域

产品概述

Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

形式

The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.

浓度

SMAD7 (NP_005895, 160 a.a. ~ 260 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

纯度

Mouse

试剂准备

Clear, colorless solution in phosphate buffered saline, pH 7.2.

复溶

Genetic Heterogeneity in Colorectal Cancer Associations in Americans of African vs European Descent. Kupfer SS, et al. Gastroenterology, 2010 Jul 24. PMID 20659471. Association studies on 11 published colorectal cancer risk loci. von Holst S, et al. Br J Cancer, 2010 Aug 10. PMID 20648012. Susceptibility genetic variants associated with colorectal cancer risk correlate with cancer phenotype. Abul? A, et al. Gastroenterology, 2010 Sep. PMID 20638935. Hypoxic conversion of SMAD7 function from an inhibitor into a promoter of cell invasion. Heikkinen PT, et al. Cancer Res, 2010 Jul 15. PMID 20551054. Risk of genome-wide association study-identified genetic variants for colorectal cancer in a Chinese population. Xiong F, et al. Cancer Epidemiol Biomarkers Prev, 2010 Jul. PMID 20530476.

储存条件

Human

储存溶液

Mothers against decapentaplegic homolog 7, MAD homolog 7, Mothers against DPP homolog 7, Mothers against decapentaplegic homolog 8, MAD homolog 8, Mothers against DPP homolog 8, SMAD family member 7, SMAD 7, Smad7, hSMAD7, SMAD7, MADH7, MADH8

应用

WB~~1:500~1000

数量

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