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当前位置:首页 > 抗原抗体、ELISA、WB > 一抗 > 单克隆抗体 > RSK4 Antibody Phospho (pS235)

RSK4 Antibody Phospho (pS235)

LM20963
货号 货期 规格 / 价格 询价

RSK4 Antibody Phospho (pS235)

品牌

Leading Biology

货号

LM20963

产品分类

单克隆抗体

研究领域

产品概述

Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

形式

RSK4 is a member of the family of 90-kDa ribosomal S6 kinases (1). These proteins are a class of serine/threonine kinases that are activated in response to various extracellular signals, including growth factors, polypeptide hormones and neurotransmitters (2). RSK4 is most abundantly expressed in brain and kidney. The predicted protein of 746 amino acids shows a high level of homology to three previously isolated members of the human RSK family. RSK2 is involved in Coffin-Lowry syndrome and nonspecific MRX. The localization of RSK4 in the interval that is commonly deleted in mentally retarded males together with the high degree of amino acid identity with RSK2 suggests that RSK4 plays a role in normal neuronal development (3).

浓度

A synthetic peptide corresponding to residues surrounding serine 235 of human Rsk 4 was used as an immunogen.

纯度

Rabbit

试剂准备

50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

复溶

1. Moller, D.E., et al. Am J Physiol. 266(2 Pt 1): C351<br>2. Frodin, M., et al. Mol. Cell. Endocrinol. 151: 65<br>3. Yntema HG, et al. Genomics 62(3):332-43, 1999.<br>

储存条件

Human, Mouse

储存溶液

Ribosomal protein S6 kinase alpha-6, S6K-alpha-6, 90 kDa ribosomal protein S6 kinase 6, p90-RSK 6, p90RSK6, Ribosomal S6 kinase 4, RSK-4, pp90RSK4, RPS6KA6, RSK4

应用

WB~~1:1000~10000 IHC~~1:50~100

产品描述

Function Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. Cellular_Location Cytoplasm, cytosol. Nucleus. Note=Predominantly cytosolic

数量

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