全部产品分类
品牌 |
Leading Biology | 货号 |
LM20911 |
产品分类 |
单克隆抗体 | 研究领域 |
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产品概述 |
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
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形式 |
Rap1, also known as Krev-1 and smg p21, is a member of the Ras super family of GTPases closely related to Ras. Two known isoforms of Rap1 exists, Rap1A and Rap1B which share 95% identity (1-2). As a molecular switch, Rap1 cycles between two conformational states depending on whether GDP bound (active form) or GTP bound (inactive form). Rap1 associates with a subset of Ras effectors including Raf-1, B-Raf, phosphoinositide 3-kinase, Ral GEFs, and PLC (3). Although its function is still unclear, Rap1 has been shown to be involved in the regulation of integrin-mediated cell adhesion (4).
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浓度 |
A synthetic peptide corresponding to residues near the N-terminus of human Rap 1 was used as an immunogen. |
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纯度 |
Rabbit |
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试剂准备 |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
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复溶 |
1. Rousseau-Merck, et al. Cytogenet. Cell Genet. 53:2-4, 1990.<br>2. Kitayama, H et al. Cell 56: 77-84, 1989.<br>3. Okada, T. et al. Mol. Cell. Biol. 19, 6057-6064, 1990<br>4. Bos, J. L., et al. Nat. Rev. Mol. Cell. Biol. 2, 369-377, 2001<br>
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储存条件 |
Human, Mouse, Rat
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储存溶液 |
Ras-related protein Rap-1A, C21KG, G-22K, GTP-binding protein smg p21A, Ras-related protein Krev-1, RAP1A, KREV1
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应用 |
WB~~1:1000~10000
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产品描述 |
Function
Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions.
Cellular_Location
Cell membrane; Lipid-anchor. Cytoplasm. Cytoplasm, perinuclear region. Cell junction. Early endosome. Note=Recruited from early endosome to late endosome compartment after nerve growth factor (NGF) stimulation Localized with RAPGEF2 at cell-cell junctions (By similarity) Colocalized with RAPGEF2 in the perinuclear region.
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数量 |
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| 选择 | 品牌 | 货号 | 产品名称 | 规格 | 分类 | 研究领域 | 说明书 | 数量 | 目录价 | |
| 1 | Swant | 2D7 | monoclonal anti-Glutamate antibody | 200 µl | 单克隆抗体 | Antibodies against neurotransmitters |
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￥5096.00 | 订购 询价 | |
| 2 | Leading Biology | LM21248 | Anti-CD36 Antibody (Rabbit Monoclonal antibody) | 100 ul | 单克隆抗体 | Chondrogenesis Markers |
|
￥4950.00 | 订购 询价 | |
| 3 | Swant | 288 | Monoclonal antibody to endothelial cells. | 单克隆抗体 |
|
￥3243.00 | 订购 询价 | |||
| 4 | Swant | 3A12 | monoclonal anti-GABA antibody | 200 µl | 单克隆抗体 | Antibodies against neurotransmitters |
|
￥5096.00 | 订购 询价 | |
| 5 | Swant | 345 | Monoclonal antibody to rat pyramidal cells. | 200 µl | 单克隆抗体 | Miscellaneous antibodies |
|
￥3243.00 | 订购 询价 | |
| 6 | Swant | 3D5 | monoclonal anti-GABA antibody | 200 µl | 单克隆抗体 | Antibodies against neurotransmitters |
|
￥5096.00 | 订购 询价 |
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