全部产品分类
品牌 |
Leading Biology | 货号 |
LM20807 |
产品分类 |
单克隆抗体 | 研究领域 |
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产品概述 |
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
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形式 |
PKA, RII is one of several regulatory subunits of the cAMP-dependent protein kinase (PKA). The kinase holoenzyme consists of two dimmers of two regulatory (R) and two catalytic (C) subunits that dissociate upon the binding of two cAMP molecules to each of the R subunits (1). Two families of R subunits (RI and RII) have been identified, each possessing distinct cAMP binding properties and resulting in different phosphorylation states (2, 3). The PKA, RII beta (RIIb) regulatory isoform is abundant in brown and white adipose tissue and brain, with limited expression elsewhere. PKA, RIIb is demonstrated to play a role in regulating energy balance and adiposity, thus making it a potential target for therapeutic intervention in obesity (4, 5). It has been shown that PKA, RIIb is essential for cAMP-induced growth inhibition and differentiation of HL-60 human leukemia cells. By binding to its ligand, cAMP, the PKA, RIIb cAMP receptor acts as a tumor suppressor protein exerting growth inhibition, differentiation, and reverse transformation (6).
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浓度 |
A synthetic peptide corresponding to residues near the C-terminus of human PKA RIIb was used as an immunogen. |
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纯度 |
Rabbit |
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试剂准备 |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
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复溶 |
1. Levy, F. O., et al. Molec. Endocr. 2: 1364-1373, 1988<br>2. Beebe, S.J., et al. Semin Cancer Biol. 5: 285<br>3. Braun, R.K, et al. Arch Biochem Biophys. 289: 187<br>4. Cummings DE, et al. Naure 382(6592):622-6, 1996<br>5. D. E. Danley, et al. Acta Cryst. D56, 1038-1041, 2000<br>6. G Tortora, et al. Cell Growth & Differentiation 5(7):753-759, 1994<br>
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储存条件 |
Human, Mouse, Rat
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储存溶液 |
cAMP-dependent protein kinase type II-beta regulatory subunit, PRKAR2B
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应用 |
WB~~1:1000~2000
IHC~~1:100~250
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产品描述 |
Function
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
Cellular_Location
Cytoplasm. Cell membrane. Note=Colocalizes with PJA2 in the cytoplasm and at the cell membrane
Tissue_Location
Four types of regulatory chains are found: I- alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible
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数量 |
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