全部产品分类
品牌 |
Leading Biology | 货号 |
LM20765 |
产品分类 |
单克隆抗体 | 研究领域 |
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形式 |
Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling.
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浓度 |
Recognizes an epitope located in the C-terminal domain of Csk-binding protein (Cbp / PAG), a 46 kD ubiquitously expressed transmembrane adaptor protein present in membrane rafts (glycosphingolipid-enriched microdomains), which however migrates on SDS ... |
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纯度 |
Mouse |
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复溶 |
Brdicka T.,et al.J. Exp. Med. 191:1591-1604(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Brdickova N.,et al.FEBS Lett. 507:133-136(2001).
Brill L.M.,et al.Anal. Chem. 76:2763-2772(2004).
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储存条件 |
Human, Mouse, Rat, Bovine
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储存溶液 |
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1, Csk-binding protein, Transmembrane adapter protein PAG, Transmembrane phosphoprotein Cbp, PAG1, CBP, PAG
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应用 |
IHC-P (15 μg/ml)
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产品描述 |
Function
Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling.
Cellular_Location
Cell membrane; Single-pass type III membrane protein. Note=Present in lipid rafts
Tissue_Location
Ubiquitously expressed. Present in germinal center B-cells, plasma cells, T-cells, monocytes and platelets (at protein level).
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数量 |
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