全部产品分类
品牌 |
Leading Biology | 货号 |
LM20643 |
产品分类 |
单克隆抗体 | 研究领域 |
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产品概述 |
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
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形式 |
This gene encodes a microtubule-associatedserine/threonine kinase. Mutations at this locus have beenassociated with autosomal dominant thrombocytopenia, also known asthrombocytopenia-2. Alternatively spliced transcript variants havebeen described for this locus.
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浓度 |
This MASTL monoclonal antibody is generated from mouse immunized with MASTL recombinant protein. |
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纯度 |
Mouse |
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试剂准备 |
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
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复溶 |
Gandhi, M.J., et al. Hum. Hered. 55(1):66-70(2003)
Drachman, J.G., et al. Blood 96(1):118-125(2000)
Savoia, A., et al. Am. J. Hum. Genet. 65(5):1401-1405(1999)
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储存条件 |
Human
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储存溶液 |
Serine/threonine-protein kinase greatwall, GW, GWL, hGWL, Microtubule-associated serine/threonine-protein kinase-like, MAST-L, MASTL, GW, GWL, THC2
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应用 |
WB~~1:100~500
IF~~1:10~50
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产品描述 |
Function
Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation.
Cellular_Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cleavage furrow Note=During interphase is mainly nuclear, upon nuclear envelope breakdown localizes at the cytoplasm and during mitosis at the centrosomes. Upon mitotic exit moves to the cleavage furrow
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数量 |
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| 选择 | 品牌 | 货号 | 产品名称 | 规格 | 分类 | 研究领域 | 说明书 | 数量 | 目录价 | |
| 1 | Swant | 2D7 | monoclonal anti-Glutamate antibody | 200 µl | 单克隆抗体 | Antibodies against neurotransmitters |
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￥5096.00 | 订购 询价 | |
| 2 | Leading Biology | LM21248 | Anti-CD36 Antibody (Rabbit Monoclonal antibody) | 100 ul | 单克隆抗体 | Chondrogenesis Markers |
|
￥4950.00 | 订购 询价 | |
| 3 | Swant | 288 | Monoclonal antibody to endothelial cells. | 单克隆抗体 |
|
￥3243.00 | 订购 询价 | |||
| 4 | Swant | 345 | Monoclonal antibody to rat pyramidal cells. | 200 µl | 单克隆抗体 | Miscellaneous antibodies |
|
￥3243.00 | 订购 询价 | |
| 5 | Swant | 3A12 | monoclonal anti-GABA antibody | 200 µl | 单克隆抗体 | Antibodies against neurotransmitters |
|
￥5096.00 | 订购 询价 | |
| 6 | Swant | 77 | mouse monoclonal antibody against rat angiotensinogen | 200 µl | 单克隆抗体 | Antibodies against components of the renin-angiotensin system |
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￥4015.00 | 订购 询价 |
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