全部产品分类
品牌 |
Leading Biology | 货号 |
LM20630 |
产品分类 |
单克隆抗体 | 研究领域 |
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产品概述 |
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
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形式 |
The protein encoded by this gene is a member of theserine/threonine kinase family. This kinase contains a SH3 domainand a leucine zipper-basic motif. This kinase preferentiallyactivates MAPK8/JNK kinase, and functions as a positive regulatorof JNK signaling pathway. This kinase can directly phosphorylate,and activates IkappaB kinase alpha and beta, and is found to beinvolved in the transcription activity of NF-kappaB mediated by Rhofamily GTPases and CDC42.
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浓度 |
This MAP3K11 monoclonal antibody is generated from mouse immunized with MAP3K11 recombinant protein. |
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纯度 |
Mouse |
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试剂准备 |
Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
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复溶 |
Chen, J., et al. Oncogene 29(31):4399-4411(2010)
Liou, G.Y., et al. Biochem. J. 427(3):435-443(2010)
Mishra, P., et al. Mol. Endocrinol. 24(3):598-607(2010)
Rangasamy, V., et al. Cancer Res. 70(4):1731-1740(2010)
Velho, S., et al. Hum. Mol. Genet. 19(4):697-706(2010)
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储存条件 |
Human
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储存溶液 |
Mitogen-activated protein kinase kinase kinase 11, Mixed lineage kinase 3, Src-homology 3 domain-containing proline-rich kinase, MAP3K11 (HGNC:6850)
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应用 |
WB~~1:100~500
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产品描述 |
Function
Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle.
Cellular_Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Location is cell cycle dependent
Tissue_Location
Expressed in a wide variety of normal and neoplastic tissues including fetal lung, liver, heart and kidney, and adult lung, liver, heart, kidney, placenta, skeletal muscle, pancreas and brain.
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数量 |
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| 选择 | 品牌 | 货号 | 产品名称 | 规格 | 分类 | 研究领域 | 说明书 | 数量 | 目录价 | |
| 1 | Swant | 2D7 | monoclonal anti-Glutamate antibody | 200 µl | 单克隆抗体 | Antibodies against neurotransmitters |
|
￥5096.00 | 订购 询价 | |
| 2 | Leading Biology | LM21248 | Anti-CD36 Antibody (Rabbit Monoclonal antibody) | 100 ul | 单克隆抗体 | Chondrogenesis Markers |
|
￥4950.00 | 订购 询价 | |
| 3 | Swant | 288 | Monoclonal antibody to endothelial cells. | 单克隆抗体 |
|
￥3243.00 | 订购 询价 | |||
| 4 | Swant | 345 | Monoclonal antibody to rat pyramidal cells. | 200 µl | 单克隆抗体 | Miscellaneous antibodies |
|
￥3243.00 | 订购 询价 | |
| 5 | Swant | 3A12 | monoclonal anti-GABA antibody | 200 µl | 单克隆抗体 | Antibodies against neurotransmitters |
|
￥5096.00 | 订购 询价 | |
| 6 | Swant | 77 | mouse monoclonal antibody against rat angiotensinogen | 200 µl | 单克隆抗体 | Antibodies against components of the renin-angiotensin system |
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￥4015.00 | 订购 询价 |
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