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当前位置:首页 > 抗原抗体、ELISA、WB > 一抗 > 单克隆抗体 > LAT Antibody (clone LAT.10-17 (10-17))

LAT Antibody (clone LAT.10-17 (10-17))

LM20597
货号 货期 规格 / 价格 询价

LAT Antibody (clone LAT.10-17 (10-17))

品牌

Leading Biology

货号

LM20597

产品分类

单克隆抗体

研究领域

形式

Required for TCR (T-cell antigen receptor)- and pre-TCR- mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.

纯度

Mouse

复溶

Zhang W.,et al.Cell 92:83-92(1998). Weber J.R.,et al.J. Exp. Med. 187:1157-1161(1998). Muschen M.,et al.Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases. Martin J.,et al.Nature 432:988-994(2004). Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

储存条件

Human

储存溶液

Linker for activation of T-cells family member 1, 36 kDa phospho-tyrosine adapter protein, pp36, p36-38, LAT

应用

IHC-P (20 μg/ml)

产品描述

Function Required for TCR (T-cell antigen receptor)- and pre-TCR- mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. Cellular_Location Cell membrane; Single-pass type III membrane protein Note=Present in lipid rafts Tissue_Location Expressed in thymus, T-cells, NK cells, mast cells and, at lower levels, in spleen. Present in T-cells but not B-cells (at protein level).

数量

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