全部产品分类
品牌 |
Leading Biology | 货号 |
LM20495 |
产品分类 |
单克隆抗体 | 研究领域 |
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产品概述 |
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
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形式 |
IRAK-3 (also known as IRAK-M) is a member of the interleukine-1 receptor-associated kinase (IRAK) family. The IRAK family is implicated in the Toll-like receptor (TLR) and Il-1R signaling pathway (1). Upon stimulation, IRAK gets phosphorylated and activates NF-kB (2). Unlike IRAK, IRAK2 and IRAK4 which are expressed ubiquitously, IRAK-3 is mostly expressed in monocytes and macrophages (3). IRAK-M and IRAK-2 lack kinase activity, while IRAK-3 has a weak capacity to be phosphorylated. Additionally, IRAK-3 has been found to negatively regulate TRL signaling to protect from endotoxic shock (5).
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浓度 |
A synthetic peptide corresponding to residues in the C-term of human IRAK-3 was used as immunogen. |
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纯度 |
Rabbit |
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试剂准备 |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
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复溶 |
1. Cao, Z., W. J. Henzel, X. Gao. 1996. Science271:11282.<br>2. Kanakaraj, P., K. Ngo, Y. Wu, A. Angulo, P. Ghazal, C. A. Harris, J. J. Siekierka, P. A. Peterson, W. P. Fung-Leung. 1999. J. Exp. Med.189:1129<br>3. H., Gao, X., Li, X., Kirschning, C.J., Stark, G.R. and Cao, Z., 1999. J. Biol. Chem. 274, pp. 19403<br>4. Muzio, M., Ni, J., Feng, P. and Dixit, V.M., 1997. Science 278, pp. 1612<br>5. Koichi Kobayashi, Lorraine D. Hernandez, Jorge E. Gal<br>
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储存条件 |
Human
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储存溶液 |
Interleukin-1 receptor-associated kinase 3, IRAK-3, IL-1 receptor-associated kinase M, IRAK-M, IRAK3 {ECO:0000312|EMBL:AAH578001}
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应用 |
WB~~1:1000
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产品描述 |
Function
Inhibits dissociation of IRAK1 and IRAK4 from the Toll- like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.
Tissue_Location
Expressed predominantly in peripheral blood lymphocytes.
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数量 |
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