全部产品分类
品牌 |
Leading Biology | 货号 |
LM20390 |
产品分类 |
单克隆抗体 | 研究领域 |
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产品概述 |
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
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形式 |
Gelsolin is a large and complex actin-binding protein that belongs to actin-severing gelsolin/villin super family. Gelsolin is a regulator of actin filament assembly and disassembly and consists of six homologous subdomains (S1-S6). When C-terminal tail (S6) is bound to calcium ion, it straightens and exposes actin binding sites located on S2s helices, leading to Gelsolin actin-serving activity (1). Gelsolin is inhibited by phosphatidylinositol (4,5)-bisphosphate (PIP2), where PIP2 will bind to S1, S2, and S3 sites. Gelsolin is involved in podosome formation and has been linked to inhibition of apoptosis by preventing release of cytochrome C (2).
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浓度 |
A synthetic peptide corresponding to residues in the C-terminal region of human Gelsolin was used as immunogen. |
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纯度 |
Rabbit |
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试剂准备 |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
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复溶 |
1. Sun, H et al. J Biol Chem 274 (47): 33179<br>2. Koya, R, et al. J Biol Chem 275 (20): 15343-15349, 2000.<br>
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储存条件 |
Human, Mouse, Rat
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储存溶液 |
Gelsolin, AGEL, Actin-depolymerizing factor, ADF, Brevin, GSN
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应用 |
IHC~~1:100~250
WB~~1:1000~5000
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产品描述 |
Function
Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.
Cellular_Location
Isoform 2: Cytoplasm, cytoskeleton.
Tissue_Location
Phagocytic cells, platelets, fibroblasts, nonmuscle cells, smooth and skeletal muscle cells
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数量 |
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| 1 | Swant | 2D7 | monoclonal anti-Glutamate antibody | 200 µl | 单克隆抗体 | Antibodies against neurotransmitters |
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| 2 | Leading Biology | LM21248 | Anti-CD36 Antibody (Rabbit Monoclonal antibody) | 100 ul | 单克隆抗体 | Chondrogenesis Markers |
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| 3 | Swant | 288 | Monoclonal antibody to endothelial cells. | 单克隆抗体 |
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| 4 | Swant | 345 | Monoclonal antibody to rat pyramidal cells. | 200 µl | 单克隆抗体 | Miscellaneous antibodies |
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| 5 | Swant | 3A12 | monoclonal anti-GABA antibody | 200 µl | 单克隆抗体 | Antibodies against neurotransmitters |
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| 6 | Swant | 77 | mouse monoclonal antibody against rat angiotensinogen | 200 µl | 单克隆抗体 | Antibodies against components of the renin-angiotensin system |
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