全部产品分类
品牌 |
Leading Biology | 货号 |
LM20385 |
产品分类 |
单克隆抗体 | 研究领域 |
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产品概述 |
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
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形式 |
In eukaryotic cells, protein synthesis is regulated in response to various environmental stresses by phosphorylating the alpha subunit of the eukaryotic initiation factor 2 (eIF2alpha). Four different eIF2alpha kinases have been identified in mammalian cells, the heme-regulated inhibitor (HRI), the interferon-inducible RNA-dependent kinase (PKR) and the endoplasmic reticulum-resident kinase (PERK) and GCN2, which was previously characterized from Saccharomyces cerevisiae, Drosophila melanogaster and Neurospora crassa. GCN2 is the unique eIF2alpha kinase present in all eukaryotes from yeast to mammals (1). GCN2, a sensor of amino acid deficiency, plays a key role in yeast and mammals in modulating amino acid metabolism as part of adaptation to nutrient deprivation. (2). Results demonstrate that PERK and GCN2 function to cooperatively regulate eIF2alpha phosphorylation and cyclin D1 translation after unfolded protein response pathway activation (3).
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浓度 |
A phospho specific peptide corresponding to residues surrounding threonine 899 of human GCN2 was used as an immunogen. This antibody detects GCN2 phosphorylyated at threonine 899. |
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纯度 |
Rabbit |
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试剂准备 |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
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复溶 |
1. Berlanga JJ, et al. Eur J Biochem 265(2):754-62<br>2. Guo F, et al. Cell Metab 5(2):103-14, 2007<br>3. Hamanaka RB, et al. Mol Bio Cell 16(12):5493-501, 2005<br>
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储存条件 |
Human
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储存溶液 |
Eukaryotic translation initiation factor 2-alpha kinase 4, GCN2-like protein, EIF2AK4, GCN2, KIAA1338
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应用 |
WB~~1:1000~2000
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产品描述 |
Function
Can phosphorylate the alpha subunit of EIF2 and may mediate translational control.
Tissue_Location
Widely expressed. Expressed in the lung in smooth muscle cells of the pulmonary vessel wall, interstitial tissue and macrophages.
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数量 |
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