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当前位置:首页 > 抗原抗体、ELISA、WB > 一抗 > 单克隆抗体 > Cytokeratin-7 Antibody (C-term)

Cytokeratin-7 Antibody (C-term)

LM20245
货号 货期 规格 / 价格 询价

Cytokeratin-7 Antibody (C-term)

品牌

Leading Biology

货号

LM20245

产品分类

单克隆抗体

研究领域

产品概述

Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

形式

Cytokeratins are cytoplasmic intermediate filament proteins expressed by epithelial cells. Keratin 7 (CK7) is expressed in a wide range of epithelial structures in humans. The expression pattern in mice is similar to the reported human distribution, with substantial expression observed in lung, bladder, mesothelium, hair follicle, and ductal structures (1). Protein expression levels of CK7 appear significantly higher in chromophobe RCC compared to oncocytoma (p < 0.001). Studies provide further evidence that CK7 and parvalbumin immunostains may be useful in differentiating oncocytoma from chromophobe RCC in problematic cases (2). Also, the pattern of immunohistochemical expression of CK 7 along with CK 20 is commonly used to assess possible primary sites of metastatic carcinomas (3).

浓度

A synthetic peptide corresponding to residues near the C-terminus of human CK-7 was used as an immunogen.

纯度

Rabbit

试剂准备

50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

复溶

1. Smith FJ, et al. Biochem Biophys Res Commun. 297(4):818-27, 2002.<br>2. Adley BP, et al. Anal Quant Cytol Histol 28(4):228-36, 2006<br>3. Coons SW, et al. Endocr Pathol 16(3):201-10, 2005.<br>

储存条件

Human

储存溶液

Keratin, type II cytoskeletal 7, Cytokeratin-7, CK-7, Keratin-7, K7, Sarcolectin, Type-II keratin Kb7, KRT7, SCL

应用

WB~~1:2000~5000

产品描述

Function Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7). Cellular_Location Cytoplasm. Tissue_Location Expressed in cultured epidermal, bronchial and mesothelial cells but absent in colon, ectocervix and liver Observed throughout the glandular cells in the junction between stomach and esophagus but is absent in the esophagus

数量

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