全部产品分类
品牌 |
Leading Biology | 货号 |
LM20229 |
产品分类 |
单克隆抗体 | 研究领域 |
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产品概述 |
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
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形式 |
KRT18 encodes the type I intermediate filament chainkeratin 18. Keratin 18, together with its filament partner keratin8, are perhaps the most commonly found members of the intermediatefilament gene family. They are expressed in single layer epithelialtissues of the body. Mutations in this gene have been linked tocryptogenic cirrhosis. Two transcript variants encoding the sameprotein have been found for this gene.
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浓度 |
This CYK18 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 401-430 amino acids from the C-terminal region of human CYK18. |
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纯度 |
Mouse |
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试剂准备 |
Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
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复溶 |
Srikanth, B., et al. J. Biol. Chem. 285(44):34062-34071(2010)
Strnad, P., et al. Gastroenterology 139(3):828-835(2010)
Yamashiro, Y., et al. Biochem. Biophys. Res. Commun. 399(3):365-372(2010)
Nagashio, R., et al. Pathol. Int. 60(2):71-77(2010)
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
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储存条件 |
Human
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储存溶液 |
Keratin, type I cytoskeletal 18, Cell proliferation-inducing gene 46 protein, Cytokeratin-18, CK-18, Keratin-18, K18, KRT18, CYK18
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应用 |
WB~~1:1000~8000
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产品描述 |
Function
Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
Cellular_Location
Cytoplasm, perinuclear region. Nucleus, nucleolus
Tissue_Location
Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.
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数量 |
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