全部产品分类
品牌 |
Leading Biology | 货号 |
LM20193 |
产品分类 |
单克隆抗体 | 研究领域 |
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形式 |
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PubMed:23407391). CLDN1 acts as a coreceptor for HCV entry into hepatic cells.
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纯度 |
Mouse |
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复溶 |
Swisshelm K.L.,et al.Gene 226:285-295(1999).
Mitic L.M.,et al.Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
Halford S.,et al.Cytogenet. Cell Genet. 88:217-217(2000).
Kraemer F.,et al.Hum. Genet. 107:249-256(2000).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
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储存条件 |
Human
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储存溶液 |
Claudin-1, Senescence-associated epithelial membrane protein, CLDN1, CLD1, SEMP1
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应用 |
IHC-P (5 μg/ml)
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产品描述 |
Function
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PubMed:23407391). CLDN1 acts as a coreceptor for HCV entry into hepatic cells.
Cellular_Location
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein
Tissue_Location
Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis
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数量 |
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| 1 | Swant | 2D7 | monoclonal anti-Glutamate antibody | 200 µl | 单克隆抗体 | Antibodies against neurotransmitters |
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| 2 | Leading Biology | LM21248 | Anti-CD36 Antibody (Rabbit Monoclonal antibody) | 100 ul | 单克隆抗体 | Chondrogenesis Markers |
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| 3 | Swant | 288 | Monoclonal antibody to endothelial cells. | 单克隆抗体 |
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| 4 | Swant | 345 | Monoclonal antibody to rat pyramidal cells. | 200 µl | 单克隆抗体 | Miscellaneous antibodies |
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￥3243.00 | 订购 询价 | |
| 5 | Swant | 3A12 | monoclonal anti-GABA antibody | 200 µl | 单克隆抗体 | Antibodies against neurotransmitters |
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| 6 | Swant | 77 | mouse monoclonal antibody against rat angiotensinogen | 200 µl | 单克隆抗体 | Antibodies against components of the renin-angiotensin system |
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