全部产品分类
品牌 |
Leading Biology | 货号 |
LM20187 |
产品分类 |
单克隆抗体 | 研究领域 |
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产品概述 |
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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形式 |
Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. This gene encodes the cartilage intermediate layer protein (CILP), which increases in early osteoarthrosis cartilage. The encoded protein was thought to encode a protein precursor for two different proteins; an N-terminal CILP and a C-terminal homolog of NTPPHase, however, later studies identified no nucleotide pyrophosphatase phosphodiesterase (NPP) activity. The full-length and the N-terminal domain of this protein was shown to function as an IGF-1 antagonist. An allelic variant of this gene has been associated with lumbar disc disease.
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浓度 |
CILP (NP_003604, 129 a.a. ~ 226 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
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纯度 |
mouse |
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试剂准备 |
Clear, colorless solution in phosphate buffered saline, pH 7.2.
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复溶 |
Cartilage Intermediate Layer Protein Gene Is Associated With Lumbar Disc Degeneration in Male, but Not Female, Collegiate Athletes. Min SK, et al. Am J Sports Med, 2010 Aug 19. PMID 20724643.The cartilage intermediate layer protein gene is associated with lumbar disc degeneration in collegiate judokas. Min SK, et al. Int J Sports Med, 2009 Sep. PMID 19569011.Phenotypic and population differences in the association between CILP and lumbar disc disease. Virtanen IM, et al. J Med Genet, 2007 Apr. PMID 17220213.Reproducible genetic associations between candidate genes and clinical knee osteoarthritis in men and women. Valdes AM, et al. Arthritis Rheum, 2006 Feb. PMID 16453284.Transcriptional regulation of the cartilage intermediate layer protein (CILP) gene. Mori M, et al. Biochem Biophys Res Commun, 2006 Mar 3. PMID 16413503.
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储存条件 |
Human
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储存溶液 |
Cartilage intermediate layer protein 1, CILP-1, Cartilage intermediate-layer protein, Cartilage intermediate layer protein 1 C1, Cartilage intermediate layer protein 1 C2, CILP
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数量 |
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