全部产品分类
品牌 |
Leading Biology | 货号 |
LM20147 |
产品分类 |
单克隆抗体 | 研究领域 |
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产品概述 |
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
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形式 |
CD3 (Cluster of Differentiation 3) is a complex of proteins that associates directly with the T cell antigen receptor (TCR) (1). Antigen binding to the TCR leads to IL-2 secretion via activation of a tyrosine phosphorylation pathway and a phospholipase C (PLC) pathway, in turn activating protein kinase C (1,2). CD3 is composed of five invariant polypeptide chains that associate to form three dimers. The five invariant chains of CD3 are labeled gamma, delta, epsilon, zeta, and eta. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways (3). Loss of the zeta chain results in the synthesis of unstable TCRs (4). A decrease of CD3 zeta has been described in T cells from patients with cancer, lupus and chronic infectious diseases (5).
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浓度 |
A synthetic peptide corresponding to residues in the C-terminus of human CD3 zeta was used as immunogen. |
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纯度 |
Rabbit |
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试剂准备 |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
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复溶 |
1. Weiss, A., et al. Sem. Immunol. 3: 313<br>2. Siegel, J.N., et al. Sem Immunol. 3: 325<br>3. Irving, B. A., and Weiss, A. (1991) Cell 64, 891-901<br>4. Minami, Y., Weissman, A.M., Samelson, L.E., and Klausner, R.D. 1987.Natl. Acad. Sci. USA. 84:2688-2692<br>5. Zea, A. H., Curti, B. D., Longo, D. L., Alvord, W. G., Strobl, S. L., Mizoguchi, H., Creekmore, S. P., O'Shea, J. J., Powers, G. C., Urba, W. J., and Ochoa, A. C. (1995) Clin. Cancer Res. 1, 1327-1335<br>
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储存条件 |
Human
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储存溶液 |
T-cell surface glycoprotein CD3 zeta chain, T-cell receptor T3 zeta chain, CD247, CD247, CD3Z, T3Z, TCRZ
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应用 |
WB~~1:500~1000
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产品描述 |
Function
Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering.
Cellular_Location
Membrane; Single-pass type I membrane protein
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数量 |
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