全部产品分类
品牌 |
Leading Biology | 货号 |
LM20076 |
产品分类 |
单克隆抗体 | 研究领域 |
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产品概述 |
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
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形式 |
This gene encodes a cytoplasmic linker or adaptor proteinthat plays a critical role in B cell development. This proteinbridges B cell receptor-associated kinase activation withdownstream signaling pathways, thereby affecting various biologicalfunctions. The phosphorylation of five tyrosine residues isnecessary for this protein to nucleate distinct signaling effectorsfollowing B cell receptor activation. Mutations in this gene causehypoglobulinemia and absent B cells, a disease in which the pro- topre-B-cell transition is developmentally blocked. Deficiency inthis protein has also been shown in some cases of pre-B acutelymphoblastic leukemia. Alternatively spliced transcript variantsencoding different isoforms have been found for this gene.
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浓度 |
This BLNK antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 150-178 amino acids from human BLNK. |
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纯度 |
Mouse |
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试剂准备 |
Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
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复溶 |
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Oellerich, T., et al. Mol. Cell Proteomics 8(7):1738-1750(2009)
Imamura, Y., et al. J. Biol. Chem. 284(15):9804-9813(2009)
Li, H., et al. PLoS ONE 4 (7), E6410 (2009) :
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储存条件 |
Human
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储存溶液 |
B-cell linker protein, B-cell adapter containing a SH2 domain protein, B-cell adapter containing a Src homology 2 domain protein, Cytoplasmic adapter protein, Src homology 2 domain-containing leukocyte protein of 65 kDa, SLP-65, BLNK, BASH, SLP65
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应用 |
WB~~1:500~8000
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产品描述 |
Function
Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR- mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.
Cellular_Location
Cytoplasm. Cell membrane. Note=BCR activation results in the translocation to membrane fraction
Tissue_Location
Expressed in B-cell lineage and fibroblast cell lines (at protein level). Highest levels of expression in the spleen, with lower levels in the liver, kidney, pancreas, small intestines and colon
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数量 |
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