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当前位置:首页 > 抗原抗体、ELISA、WB > 一抗 > 单克隆抗体 > ATG14L Antibody

ATG14L Antibody

LM20055
货号 货期 规格 / 价格 询价

ATG14L Antibody

品牌

Leading Biology

货号

LM20055

产品分类

单克隆抗体

研究领域

产品概述

Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

纯度

Mouse

复溶

1.Mol Cell Biol. 2013 Sep;33(18):3675-88. 2.J Biol Chem. 2012 Nov 9;287(46):39107-14.

储存条件

Human

储存溶液

Beclin 1-associated autophagy-related key regulator, Barkor, Autophagy-related protein 14-like protein, Atg14L, ATG14, KIAA0831

应用

E~~1/10000 WB~~1/500 - 1/2000 IHC~~1/200 - 1/1000

产品描述

Function Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans-Golgi network to autophagosomes. Enhances PIK3C3 activity in a BECN1-dependent manner. Cellular_Location Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein. Preautophagosomal structure membrane; Peripheral membrane protein. Note=Cytosolic under nutrient-rich conditions. Following autophagy stimuli, such as starvation or rapamycin induction, predominantly detected in cytoplasmic foci, identified as isolation membranes and autophagosomes. Accumulates on highly curved PtdIns(3)P enriched autophagic membrane via its BATS domain to sense and maintain membrane curvature (By similarity). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme (By similarity)

数量

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