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OxiSelect? DNA Double-Strand Break (DSB) Staining Kit

货号 货期 规格 / 价格 询价
STA-321 100 assays / ¥8493

OxiSelect? DNA Double-Strand Break (DSB) Staining Kit

品牌

Cell Biolabs

货号

STA-321

产品分类

ELISA试剂盒

研究领域

Cell biology

产品概述

Double-strand breaks (DSB) in DNA are among the most dangerous types of DNA damage occuring within cells. One of the earliest cellular responses to double-strand breaks?is the phosphorylation of a histone variant, H2AX, at the sites of DNA damage. Within seconds Ser139 is phosphorylated when DSBs are induced in mammalian cells. Phosphorylation of this serine residue causes chromatin condensation and appears to play a critical role in the recruitment of repair or damage-signaling factors to the DNA damage sites. The?OxiSelect? DNA Double-Strand Break Staining Kit provides an easy-to-use method for detecting the presence of DSBs in cells cultured in microtiter plates. Double strand breaks can be detected in just a few hours by immunofluorescence staining of the phosphorylated histone H2AX.

储存条件

-20oC

数量

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