全部产品分类
品牌 |
Leading Biology | 货号 |
AMM06644G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Neuropeptide Y2 Receptor antibody.
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分子量 |
42628 Da
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宿主 |
Rabbit
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种属反应性 |
Rat
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靶点 |
Peptide CEQRLDAIHSEVSMTFKAK, corresponding to amino acid residues 346-364 of mouse NPY2R (Accession P97295). Intracellular, C-terminus.
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基因ID |
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UniProt ID |
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总结 |
Neuropeptide Y (NPY) is a 36-amino acid peptide neurotransmitter in the central (CNS) and peripheral nervous systems.1It belongs to the NPY family, together with peptide YY (PYY) and pancreatic polypeptide (PP). NPY is involved in regulation of a broad range of homeostatic functions such as eating behavior, hypertension, and reproduction.2NPY exerts its effects via five receptor subtypes known as the neuropeptide Y receptors (NPYR): Y1(NPY1R), Y2(NPY2R), Y4(NPY4R), Y5(NPY5R), and Y6(NPY6R).2Four of these, Y1, Y2, Y4, and Y5, are expressed in humans.2The NPY receptors belong to the G protein-coupled receptor superfamily whose members share a common structure of seven putative transmembrane domains, an extracellular amino terminus, and a cytoplasmic carboxyl terminus.Activation of these receptors by NPY produces effects on [Ca2+]i, adenylate cyclase, and a number of ion channels.3Based on the high frequency and density of NPY receptors in steroid hormone-producing tumors, the NPY receptors might be of potential use in tumor management.2NPY2R is primarily expressed in neurons as a presynaptic receptor. It is also strongly expressed in epithelia of the visceral tissues, including colon and kidney.4NPY2R is involved in inhibition of neurotransmitter release mediated by NPY.5Release of glutamate, the principal neuroexcitatory transmitter, is inhibited via the NPY2R receptor.6Involvement of NPY2R in feeding behavior was also reported. PYY(3–36), an NPY2R agonist, acts to inhibit feeding via NPY2R.7
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形式 |
Affinity purified antibody, Liquid
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB
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稀释方法 |
WB~~1:200-1:2000
IHC~~1:100
ICC~~1:100
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别名 |
Neuropeptide Y receptor type 2, NPY2-R, NPY-Y2 receptor, Y2 receptor, Npy2r
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图像 |
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说明书 |
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数量 |
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