>
抗原抗体、ELISA、WB >
一抗 >
Monoclonal Antibodies >
MART-1 / Melan-A / MLANA (Melanoma Marker) Antibody品牌 |
Leading Biology | 货号 |
AMM00687G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
|
产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality MART-1 / Melan-A / MLANA (Melanoma Marker) Antibody.
|
||
分子量 |
20-22kDa (doublet)
|
||
细胞定位 |
Antigen Cellular Localization:
Endoplasmic reticulum membrane; Single-pass type III membrane protein. Golgi apparatus. Golgi apparatus, trans-Golgi network membrane. Melanosome. Note=Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post- Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation
|
||
宿主 |
Mouse
|
||
种属反应性 |
Human, Mouse, Rat, Drosophila
|
||
克隆号 |
SPM555
|
||
亚型 |
Mouse / IgG1, kappa
|
||
通用名 |
MART1
|
||
基因ID |
|||
UniProt ID |
|||
功能 |
Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.
|
||
总结 |
This antibody recognizes a protein doublet of 20-22kDa, identified as MART-1 (Melanoma Antigen Recognized by T cells 1) or Melan-A. MART-1 is a newly identified melanocyte differentiation antigen recognized by autologous cytotoxic T lymphocytes. Seven other melanoma associated antigens recognized by autologous cytotoxic T cells include MAGE-1, MAGE-3, tyrosinase, gp100, gp75, BAGE-1, and GAGE-1. Subcellular fractionation shows that MART-1 is present in melanosomes and endoplasmic reticulum. This MAb labels melanomas and other tumors showing melanocytic differentiation. It is also a useful positive-marker for angiomyolipomas. It does not stain tumor cells of epithelial, lymphoid, glial, or mesenchymal origin.
|
||
形式 |
Liquid
|
||
储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
|
||
应用 |
WB, IHC, IF, FC
|
||
图像 |
Formalin-fixed, paraffin-embedded human Melanoma stained with Melan-A Monoclonal Antibody (SPM555). |
||
说明书 |
|||
数量 |
|
选择 | 品牌 | 货号 | 产品名称 | 规格 | 分类 | 研究领域 | 说明书 | 数量 | 目录价 | |
1 | Leading Biology | APG01369G | VEGF (Vascular Endothelial Growth Factor) Antibody - Without BSA and Azide | 100 μg | Monoclonal Antibodies |
|
¥4950.00 | 订购 询价 | ||
2 | Leading Biology | AMM07627G | RIN2 Antibody (monoclonal) (M01) | 100 μg | Monoclonal Antibodies |
|
¥4950.00 | 订购 询价 | ||
3 | Leading Biology | APR15980G | FGG Antibody | 100 μl | Monoclonal Antibodies |
|
¥5450.00 | 订购 询价 | ||
4 | Leading Biology | AMM05161G | GOB5 / CLCA1 Antibody (clone 1C4) | 50 μg | Monoclonal Antibodies |
|
¥5450.00 | 订购 询价 | ||
5 | Leading Biology | APR17667G | ORAI1 Antibody [3F6H5] | 0.1 mg | Monoclonal Antibodies |
|
¥6950.00 | 订购 询价 | ||
6 | Leading Biology | AMM04710G | GAPDH [12D3H9] Antibody | 0.1 mg | Monoclonal Antibodies |
|
¥6950.00 | 订购 询价 |
微信扫描二维码,随时随地与小诺亲密接触,精彩活动,劲爆优惠,触手可得!