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System Biosciences,简称SBI，美国加州湾区新成立的生技公司，致力于独特、创新生物技术之开发，以研发利于基因及蛋白质功能鉴定、研究之崭新方法和工具为宗旨。 现阶段研发重心为RNA干扰（RNAi）研究之相关工具。System Biosciences （SBI） 致力于开发独特、革新的技术，为客户研究蛋白组学和基因组学功能提供研究工具。SBI 是专业的慢病毒产品公司，提供基于慢病毒.
System Biosciences (SBI) develops innovative research tools for Vector delivery technologies, MicroRNA research, Exosome research, and Genome Engineering tools, including the CRISPR-Cas9 SmartNuclease™ system and PrecisionX™ HR targeting vectors.
Highlights:
Vector Technologies:
• Powerful lentivector systems
• One-step transfection piggyBac transposons
• Single-copy gene additions with phiC31 integrase vectors
• Sustained expression without integration with Minicircle DNA plasmids
Exosome Research Tools:
• Isolate exosomes with ExoQuick and ExoQuick-TC
• Exo-Flow- Immunopurify exosomes on magentic beads and anlayze by FACS
• Culture cells in exosome-depleted FBS
• Verify exosome recovery with antibodies
• Quantitate exosomes with ELISAs
Genome Engineering:
• RNA-guided Cas9 SmartNuclease system
• Fast and efficient mutation correction / gene editing
• HR donor vectors for knock-in, knock-out & tagging
• High-throughput, targeted integration with PinPoint technology
Stem Cell Research:
• iPSC reprogramming systems
• Growth factors and media
• Pluripotency confirmation kits and antibodies
• iPS celllines, normal and disease models
• Promoter lineage reporters in lentivectors
Non-coding RNA:
• LncRNA qPCR profiling kits
• miRNome and OncoMir qPCR profiling systems
• Lenti-miR Precursor clone libraries – arrayed and pooled
• miRZip anti-miR clones for stable miRNA inhibition Exo-NGS
Custom Service:
• Provide serum, tissue culture media, or other patient biofluids to SBI
• SBI isolates exosomes, purifies RNA and generates high quality NGS libraries
• Sequencing performed using Illumina MiSeq and HiSeq platforms
• Comprehensive data analysis, including generation of heat maps and top hits, provided
• NGS data loaded onto a custom UCSC Genome Browser for convenient viewing.
产品列表：
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Lentiviral Technology
Genome Engineering
Molecular Tools
Minicircle Technology Stem Cell Research
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MicroRNA Research
Exosome Research
LncRNA Research RNAi Libraries
Gene Analysis
Immunology Research
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